Welcome to the 
ASSESS* study
website!

ASSESS is a Phase 2a clinical study with an investigational drug for patients with Alport syndrome and signs of impaired kidney function.

*ASSESS (Alport Syndrome Sema3A Efficacy and Safety Study)

Alport syndrome is caused by changes in genes that produce type 4 collagen, a protein found in the body’s cells. This syndrome may cause problems in the organs where this type of collagen is present, such as the ears, eyes, and kidneys.

What is the purpose of the study?

The main purpose of the ASSESS study is to look into whether the investigational drug can reduce the decline in kidney function in patients with Alport syndrome. The study will also evaluate the safety of the investigational drug and record any side effects experienced by participants.

It is not known whether participants will receive any benefit from this study. As with any drug, side effects may occur with the investigational drug.

Who can participate?

Patients with Alport Syndrome are invited to join the ASSESS study. Are you interested in joining, or do you know someone who might be? Check below to find out more about who can participate in this study!

  • check You have been diagnosed with Alport syndrome
    • Autosomal recessive Alport syndrome (ARAS) if you are female
    • ARAS or X-linked Alport syndrome (XLAS) if you are male
  • check You have high urine albumin, a sign of kidney damage (UACR ≥ 500 mg/g)
  • check You have an eGFR value (a blood test that measures kidney function) of 45 mL/min/1.73m² or higher
  • check You are taking ACE inhibitors and/or Angiotensin II Receptor Blockers (ARBs)*
     * Patients without ACE and/or ARB therapy might also be able to participate. Conditions apply.
  • check You are between 18 and 45 years old
  • check You are not pregnant or breastfeeding

Find out where to participate and how to get in touch!

Zoom in on the map to find the nearest hospital or clinic participating in the ASSESS study.
Once you’ve found a site near you, call or send an email to speak with the study team.

Additional information

Find out more about the ASSESS study.

download_for_offline

Study Leaflet
DOWNLOAD